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KMID : 0359919930120040674
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Korean Journal of Nephrology
1993 Volume.12 No. 4 p.674 ~ p.676
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Use of Granulocyte-Macropharge Clony Stimulating Factor(GM-CSF) in Azathioprine-induced Leukopenic Renal Transplant Recipients
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진동찬
윤영석/김석영/최의진/방병기
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Abstract
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Leukopenia is often occured in kidney transplant recipients who received azathioprine (Aza) as immunosuppressive regimen. GM-CSF can be used for early bone marrow reconvery. We report the use of GM-CSF (Lucky-BiotecR, Korea) in 9 cases of
Aza-induced
leukopenic renal transplant recipients. Nin patientss (8male/1 female, mean 36 yr-old, mean posttranplant follow up 18.1 months, mean serum creatinine 3.2 mg/dl) received Aza (mean 97.2 mg/day with prednisone 13.3mg/day) and developed leuk openia
to
1,378/㎣of WBC count. These patients were administered CM-CSF with 200~400μg/day s.c. for 3 to 9 days after prompt cessation of Aza. Post GM-CSF therapy mean WBC count were detected.
In conclusion, GM-CSF can be useful for carly bone marrow recovery in leukopenic renal transplant recipients.
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